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神戸・三宮　皮膚科　びとう皮膚科クリニック　アトピー性皮膚炎、いぼ、にきび、アレルギー

開院のご挨拶

この度　三宮駅近くにて『びとう皮膚科クリニック』を開設し、八月一日より診療を開始させていただくことになりました。
神戸大学医学部附属病院、産業医科大学病院及び神戸市立医療センター西市民病院在職中は公私にわたり一方ならぬ御高配を賜り厚く御礼申し上げます。
今後はこれ迄の経験を生かすとともに更に研鑽を積んで、微力ながら地域医療の向上に尽くす所存でございます。より一層の御指導と御鞭撻のほど何卒宜しくお願い申し上げます。

院長紹介

氏名

尾藤　利憲（びとう　としのり）

生年月日

昭和４０年７月４日生

略歴

昭和６０年　４月　神戸大学医学部入学
平成　４年　６月　神戸大学医学部附属病院皮膚科研修医
平成　９年　３月　神戸大学医学部大学院修了　医学博士
平成　９年　８月　日本皮膚科学会認定皮膚科専門医取得
平成１０年　４月　カリフォルニア州立大学バークレー校
　　　　　　　　　分子生物学教室（Packer教授）客員研究員として留学
平成１２年　７月　神戸大学医学部附属病院皮膚科助手
（平成１３年　８月～平成１７年８月　医局長）
平成１７年１１月　神戸市立医療センター西市民病院（前神戸市立西市民病院）皮膚科副医長
平成１８年　４月　同　皮膚科医長
平成２０年　４月　産業医科大学皮膚科（主任：戸倉新樹教授）講師
（平成２０年　４月～平成２１年３月　外来医長）
平成２２年　４月　神戸大学医学部附属病院皮膚科　講師
（平成２３年１１月～平成２４年８月　病棟医長）
平成２５年　８月　びとう皮膚科クリニック開院

学位および学会認定資格

医学博士（神戸大学）
日本皮膚科学会認定皮膚科専門医

専門分野

皮膚疾患一般
皮膚腫瘍
皮膚アレルギー性疾患
乾癬

所属学会

日本皮膚科学会
日本アレルギー学会
日本皮膚アレルギー学会
日本皮膚悪性腫瘍学会
日本研究皮膚科学会

業績（2010-2015）

欧文論文

原著

1. Yamamoto K, Shinomiya K, Ioroi T, Hirata S, Harada K, Suno M, Nishioka T, Kume M, Makimoto H, Nakagawa T, Hirano T, Bito T, Nishigori C, Miyake H, Fujisawa M, Hirai M. Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients. Target Oncol. 2015 Aug 25
2. Yamamoto K, Mizumoto A, Nishimura K, Uda A, Mukai A, Yamashita K, Kume M, Makimoto H, Bito T, Nishigori C, Nakagawa T, Hirano T, Hirai M. Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3). PLoS One. 2014;9:e102110.
3. Yamamoto K, Uda A, Mukai A, Yamashita K, Kume M, Makimoto H, Bito T, Nishigori C, Hirano T, Hirai M. Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition. J Exp Clin Cancer Res. 2013;32:83.
4. Bito T, Nishikawa R, Hatakeyama M, Kikusawa A, Kanki H, Nagai H, Sarayama Y, Ikeda T, Yoshizaki H, Seto H, Adachi A, Horikawa T, Oka M, Nishigori C. Influence of neutralizing antibodies to adalimumab and infliximab on the treatment of psoriasis. Br J Dermatol. 2014, 170:922-9.
5. Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe J, Shimauchi T, Ito T, Hirakawa S, Hirasawa N, Ogasawara K, Tokura Y. High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis. J Dermatol Sci. 2013;72:240-5.
6. Sakaguchi M, Bito T, Oda Y, Kikusawa A, Nishigori C, Munetsugu T, Yokozeki H, Itotani Y, Niguma T, Tsuruta D, Tateishi C, Ishii N, Koga H, Hashimoto T. Three cases of linear IgA/IgG bullous dermatosis showing IgA and IgG reactivity with multiple antigens, particularly laminin-332.JAMA Dermatol. 2013;149:1308-13
7. Sawada Y, Nakamura M, Bito T, Sakabe JI, Kabashima-Kubo R, Hino R, Kobayashi M, Tokura Y. Decreased Expression of Acetylcholine Esterase in Cholinergic Urticaria with Hypohidrosis or Anhidrosis. J Invest Dermatol. 2014;134:276-9.
8. Bito T, Sawada Y, Tokura Y. Pathogenesis of cholinergic urticaria in relation to sweating. Allergol Int. 2012;61:539-44.
9. Kabashima-Kubo R, Nakamura M, Sakabe J, Sugita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y. A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: possible immunological state of the intrinsic type. J Dermatol Sci. 2012;67:37-43.
10. Bito T, Nishigori C. Impact of reactive oxygen species on keratinocyte signaling pathways. J Dermatol Sci. 2012;68:3-8.
11. Masuoka E, Bito T, Shimizu H, Nishigori C. Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide. Photodermatol Photoimmunol Photomed. 2011;27:328-30.
12. Shoko Fukamachi, Tomoko Mori, Jun-Ichi Sakabe, Noriko Shiraishi, Etsushi Kuroda, Miwa Kobayashi, Toshinori Bito, Kenji Kabashima, Motonobu Nakamura, Yoshiki Tokura:Topical cholecystokinin depresses itch-associated scratching behavior in mice. J Invest Dermatol, 2011, 131:956-961
13. Bito T, Kabashima R, Sugita K, Tokura Y. Angiolymphoid hyperplasia with eosinophilia on the leg successfully treated with T-helper cell 2 cytokine inhibitor suplatast tosilate. J Dermatol, 2011, 38: 300-302.
14. Shoko Fukamachi, Toshinori Bito, Noriko Shiraishi, Miwa Kobayashi, Kenji Kabashima, Motonobu Nakamura, Yoshiki Tokura. Modulation of semaphorin 3A expression by calcium concentration and histamine in human keratinocytes and fibroblasts. J Dermatol Sci. 2011, 61: 118-123.
15. Matsugo S, Bito T, Konishi T. Photochemical stability of lipoic acid and its impact on skin ageing. Free Radic Res. 2011;45:918-24.
16. Yu Sawada, Toshinori Bito, Reiko Kabashima, Kazunari Sugita, Motonobu Nakamura, Yoshiki Tokura. Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis. Eur J Dermatol, 2011, 21(1): 99-100.
17. Bito T, Sumita N, Ashida M, Budiyanto A, Ueda M, Ichihashi M, Tokura Y, Nishigori C：Inhibition of epidermal growth factor receptor and PI3K/Akt signaling suppresses cell proliferation and survival through regulation of Stat3 activation in human cutaneous squamous cell carcinoma. J Skin Cancer, 2011, 2011:874571.
18. Bito T, Izu K, Tokura Y : Evaluation of toxicity and Stat3 activation induced by hydrogen peroxide exposure to the skin in healthy individuals. J Dermatol Sci. 2010;58(2):157-9.
19. Yoshiki R, Kabashima K, Sakabe J, Sugita K, Bito T, Nakamura M, Malissen B, Tokura Y : The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression. J Immunol. 2010;184(10):5670-7.
20. Bito T, Sumita N, Masaki T, Shirakawa T, Ueda M, Yoshiki R, Tokura Y, Nishigori C. Ultraviolet light induces Stat3 activation in human keratinocytes and fibroblasts through reactive oxygen species and DNA damage. Exp Dermatol. 2010 ;19(7):654-60.
21. Kabashima R, Hino R, Bito T, Kabashima K, Nakamura M, Bungo O, Hashimoto T, Tokura Y. Epidermolysis bullosa acquisita associated with psoriasis. Acta Derm Venereol. 2010;90(3):314-6.
22. Sawada Y, Nakamura M, Bito T, Fukamachi S, Kabashima R, Sugita K, Hino R, Tokura Y. Cholinergic urticaria: studies on the muscarinic cholinergic receptor M3 in anhidrotic and hypohidrotic skin. J Invest Dermatol. 2010;130:2683-6
23. Amalia H, Sasaki R, Suzuki Y, Demizu Y, Bito T, Nishimura H, Okamoto Y, Yoshida K, Miyawaki D, Kawabe T, Mizushina Y, Sugimura K. Vitamin K2-derived Compounds Induce Growth Inhibition in Radioresistant Cancer Cells. Kobe J Med Sci. 2010;56:E38-49.

症例報告

1. Taguchi K, Oka M, Bito T, Nishigori C. Acute generalized exanthematous pustulosis induced by Mycoplasma pneumoniae infection. J Dermatol. 2016 ;43(1):113-4. doi: 10.1111/1346-8138.13151.
2. Tajima S, Bito T, Ikeda T, Mukohara T, Nishigori C. Cutaneous endometrial cancer arising from heterotopic endometriosis in an abdominal caesarean section scar. J Eur Acad Dermatol Venereol. 2015 26. doi: 10.1111/jdv.12964.Hayashi R, Bito T, Taniguchi-Ikeda M, Farooq M, Ito M, Shimomura Y.Japanese case of oculodentodigital dysplasia caused by a mutation in the GJA1 gene. J Dermatol. 2014;41:1109-10.
3. Furumatsu A, Shimizu H, Bito T, Funasaka Y, Nishigori C. Large plaque-type benign cephalic histiocytosis showing rapid aggravation following vaccination. Cutis. 2014 ;94:E13-4.
4. Omori M, Bito T, Yamada M, Ogura K, Eishi Y, Nishigori C. Systemic sarcoidosis with bone marrow involvement showing Propionibacterium acnes in the lymph nodes. J Eur Acad Dermatol Venereol. 2015. 2059-2060.
5. Omori M, Bito T, Nishigori C. Acquired tufted angioma in pregnancy showing expression of estrogen and progesterone receptors. 2013, 23:898-9.
6. Ogawa S, Fukunaga A, Kanata M, Kikuzawa A, Bito T, Otsuka Y, Sekiguchi K, Oka N, Nishigori C. Neurolymphomatosis Associated with Erythrodermic Mycosis Fungoides. Acta Derm Venereol. 2013, 94:227-8.
7. Kyo S, Oka M, Bito T, Hatakeyama M, Kunisada M, Nishigori C.Ciliated cyst of the vulva in an elderly woman. Eur J Dermatol. 2012, 22:559-60.
8. Terai M, Oka M, Tsujimoto M, Kunisada M, Tada S, Bito T, Nishigori C. Recalcitrant pruritic urticarial papules and plaques of pregnancy with a prolonged course after delivery. Eur J Dermatol. 2012;22:136-7.
9. Washio K, Bito T, Ono R, Horikawa T, Nishigori C. Syringomatous carcinoma on the leg. J Dermatol. 2012;39:1041-3.
10. Matsumoto R, Bito T, Washio K, Ikeda T, Oka M, Manabe T, Nishigori C. Primary cutaneous small cell carcinoma of the vulva arising from squamous cell carcinoma. Br J Dermatol. 2011;165:1147-8.
11. Kishigami K, Bito T, Fujiwara N, Nishigori C, Hisaoka M, Shimajiri S. Dermatofibrosarcoma protuberans presenting with a subcutaneous mass in a 12-year-old boy. Int J Dermatol. 2013 ;52:1575-7.
12. Bito T, Kabashima R, Sugita K, Tokura Y : Angiolymphoid hyperplasia with eosinophilia on the leg successfully treated with Th2 cytokine inhibitor suplatast tonsilate J Dermatol. 2010, 38:300-2.
13. Nishitani N, Bito T, Ikeda T, Tokura Y, Nishigori C. Complete remission of metastatic malignant melanoma after surgery in association with development of systemic vitiligo. J Dermatol. 2010;37:770-2.
14. Sawada Y, Bito T, Kabashima R, Yoshiki R, Hino R, Nakamura M, Shiraishi M, Tokura Y. Ectopic extramammary Paget's disease: case report and literature review. Acta Derm Venereol. 2010;90:502-5.
15. Bito T, Kawakami C, Shimajiri S, Tokura Y. Generalized eruptive xanthoma with prominent deposition of naked chylomicrons: evidence for chylomicrons as the origin of urate-like crystals. J Cutan Pathol. 2010;37:1161-3.
16. Sawada Y, Nakamura M, Bito T, Haruyama S, Kabashima R, Sugita K, Kobayashi M, Kabashima K, Tokura Y. Chondrodermatitis of the auricle in patients with atopic dermatitis. Eur J Dermatol. 2010 20:813-4.
17. Sawada Y, Bito T, Kawakami C, Shimauchi T, Nakamura M, Tokura Y. Erosive Pustular Dermatosis of the Scalp and Leg Associated with Myasthenia Gravis: A Possible Pathogenetic Role for Neutrophil-stimulating Cytokines and Chemokines. Acta Derm Venereol. 2010;90:652-3.

邦文論文

著書

1. 尾藤利憲：乾癬患者にとっての生物学的製剤の意義と適応について　日皮臨会誌 712, 2015
2. 尾藤利憲：疥癬・ケジラミ症, 今日の治療指針 2014年版 福井次矢、高木誠、小室一成編　医学書院 1126, 2014
3. 尾藤利憲：汗をかく時期になると症状が悪化する患者に対して処方する際のポイントは？抗ヒスタミン薬?達人の処方箋Rx?　 メディカルレビュー社
4. 尾藤利憲：51温熱蕁麻疹の鑑別診断・治療　皮膚科臨床アセット 16 蕁麻疹・血管性浮腫 パーフェクトマスター　古江増隆総編集、秀道弘専門編集　中山書店
5. 尾藤利憲：59特発性の血管性浮腫の病態と治療　　皮膚科臨床アセット 16 蕁麻疹・血管性浮腫 パーフェクトマスター　古江増隆総編集、秀道弘専門編集　中山書店
6. 尾藤利憲：黄色腫症　今日の治療指針 2013年版　山口徹、北原光夫、福井次矢編　医学書院　1051-1052, 2013
7. 尾藤利憲：放射線皮膚炎　今日の皮膚疾患治療指針第4版　塩原哲夫、宮地良樹、渡辺晋一、佐藤伸一　医学書院　587-589, 2012
8. 尾藤利憲：汗アレルギー　1冊でわかる皮膚アレルギー（皮膚科サブスペシャリティーシリーズ）宮地良樹、清水宏、塩原哲夫（ゲスト編集）文光堂　287-290, 2012
9. 尾藤利憲：形質細胞あるいは肥満細胞浸潤を特徴とする皮膚疾患，How to 皮膚病理，Derma, 2011, 177, 153-159.
10. 尾藤利憲：金属アレルギー、汗アレルギー. ファーストステップ皮膚免疫学　戸倉新樹　編　中外医学社　116-123, 2010.
11. 尾藤利憲：特殊な接触皮膚炎, メディカルレビュー社, 2010